Wednesday, February 22, 2012

Opening of new drugs to treat resistant...

Reports

increase in European patients with infections that are almost impossible to treat. European Centre for Disease Control and Prevention (ECDC) said yesterday that in some countries to 50 percent of cases of blood poisoning caused by an error - K. pneumonia, a common cause of urinary and respiratory tract - were resistant to karbapenemam, the most powerful class of antibiotics. In Europe, the proportion of resistant karbapenemam K. pneumonia doubled from 7 percent to 15 percent. ECDC said that it is of particular concern because karbapenemy is the last line of antibiotics to treat drug-resistant infections. Marc Sprenger, Director, said the situation is critical. We must declare war against these bacteria. In 2009, resistant to karbapenemam K. pneumonia was established only in Greece, but by 2010 it extended to Italy, Austria, Cyprus and Hungary. The bacterium is present in the gastrointestinal tract and is transmitted through touch. Resistant strains of E. coli also increased in 2010. Between 25 and 50 percent of E. coli infection in Italy and Spain were resistant to fluoroquinolones in 2010, one of the most important antibiotics to treat bacteria. In the UK, 70 patients were found of NDM-1, containing bacteria, the enzyme that breaks down karbapenemy. Some studies have shown that over 80 percent of travelers returning from India to Europe by NDM genes in their intestines. Researchers talk about a nightmare scenario, if gene NDM-1 production is more widespread. Public Health Agency of UK doctors warned last month to give up drugs commonly used to treat the common sexually transmitted diseases, because it is not effective. Agency said that gonorrhea - which caused 17,000 infections in 2009 - should be treated with two drugs instead of one and warned about the real threat of untreatable gonorrhea in the future. Opening of new drugs to treat resistant superbakteriy was more complex and expensive business - they are taken only for short periods and business profits are low. The European Commission today launched a plan to expand research in the field of new antibiotics, for accelerated approval of promising new drugs and tools for development through the innovative medicines initiative, public-private collaboration with the pharmaceutical industry. An estimated 25,000 people die each year in the European Union of antibiotic-resistant bacterial infections. Countries with the highest rates of persistent infections, such as Greece, Cyprus, Italy, Hungary and Bulgaria, and usually those with the highest use of antibiotics. World Health Organization scientists warned two years ago that excessive use of antibiotics risked returning the world to doantibioticheskuyu era in which the infection is treatable. Warnings were ignored. Professor Laura Piddock, president of the British Society of Antimicrobial Chemotherapy, said politicians and the public has been slow to assess the severity of the situation. The journal The Lancet, she writes: Antibiotics are not perceived as essential for health, in spite of these features save lives. Global action for development of new antibiotics is not necessary, she says. Ministry of Health has published guidance aimed at deterring excessive use of antibiotics in hospitals, avoiding long-term treatment and replace broad-spectrum strattera 25mg antibiotics with those targeted at specific infections. Professor Dame Sally Davies, the chief medical expert, said: Many antibiotics prescribed ... when they should be. Example: Holiday fever, which for two months to monitor in August 2010 Paolo, 55, professor at the University of Rome, was on vacation on the island Ponzi when he fell ill with fever and chills. He had a urinary tract infection and his brother-in-law, a doctor prescribed an antibiotic called ciprofloxacin is widely used. Three days later he was no better and more feverish, but continued the drug for a week. He returned to the mainland, where his urine was tested and found to be infected with a strain of Escherichia coli resistant to many antibiotics, including ciprofloxacin. He was prescribed another antibiotic, which he took for four weeks. It was better, but four days after cessation of treatment, his symptoms returned, and he became feverish again. Then he called one, a specialist in infectious diseases, which suggested that 1/3 antibiotic, which he took for 21 days. Two months after starting treatment that finally cured of his infection. .

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